Atypical subpopulations of "innate-like" B lymphocytes.

Regardless of their ability to differentiate into antibody-producing cells, B lymphocytes can perform "innate-like" functions, dependent on unconventional activation pathways (eg. through TLRs). These cells are capable of producing pro- or anti-inflammatory cytokines to regulate different immunological functions. Examples of these "rare" populations of B cells are the so-called ABCs (Age Associated B cells) or regulatory B lymphocytes (Breg).